Secondary circulation in natural streams

Secondary circulation which is sometimes referred to as secondary flow, secondary current or transverse current is an important phenomenon in natural streams and plays an important role in many natural processes in streams such as stream channel meander, bank erosion, bed scour, resuspension, and movement of sediment. Secondary circulation is that component of flow which is not in the main flow direction and is small as compared to the main flow velocity. A computerized data collection system for secondary circulation data acquisition in natural streams was developed and utilized in the field. The system includes an electromagnetic current meter, a micro-computer, an interface between the computer and the current meter, and a specially designed supporting structure. Secondary circulation data was collected in the Sangamon River near Mahomet, Illinois, utilizing the data collection system. A mathematical model for secondary circulation based on an existing model has been developed and tested against the data collected in the field. Model results generally reproduce similar secondary circulation patterns as observed from the field data but over-estimate the magnitudes of the velocities.U.S. Department of the InteriorU.S. Geological SurveyOpe

Study of the effect of contact force model on the dynamic response of mechanical systems with dry clearance joints : computational and experimental approaches

The main objective of this work is to present a computational and experimental study on the contact forces developed in revolute clearance joints. For this purpose, a well-known slider-crank mechanism with a revolute clearance joint between the connecting rod and slider is utilized. The intra-joint contact forces that generated at this clearance joints are computed by considered several different elastic and dissipative approaches, namely those based on the Hertz contact theory and the ESDU tribology-based for cylindrical contacts, along with a hysteresis-type dissipative damping. The normal contact force is augmented with the dry Coulomb’s friction force. In addition, an experimental apparatus is use to obtained some experimental data in order to verify and validate the computational models. From the outcomes reported in this paper, it is concluded that the selection of the appropriate contact force model with proper dissipative damping plays a significant role in the dynamic response of mechanical systems involving contact events at low or moderate impact velocities.Fundação para a Ciência e a Tecnologia (FCT

Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

peer reviewedBackground: The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy of benralizumab for patients with severe eosinophilic asthma. Patients from ANDHI DB could join the 56-week ANDHI in Practice (IP) single-arm, open-label extension substudy. Objective: Assess potential for standard-of-care background medication reductions while maintaining asthma control with benralizumab. Methods: Following ANDHI DB completion, eligible adults were enrolled in ANDHI IP. After an 8-week run-in with benralizumab, there were 5 visits to potentially reduce background asthma medications for patients achieving and maintaining protocol-defined asthma control with benralizumab. Main outcome measures for non–oral corticosteroid (OCS)-dependent patients were the proportions with at least 1 background medication reduction (ie, lower inhaled corticosteroid dose, background medication discontinuation) and the number of adapted Global Initiative for Asthma (GINA) step reductions at end of treatment (EOT). Main outcomes for OCS-dependent patients were reductions in daily OCS dosage and proportion achieving OCS dosage of 5 mg or lower at EOT. Results: For non–OCS-dependent patients, 53.3% (n = 208 of 390) achieved at least 1 background medication reduction, increasing to 72.6% (n = 130 of 179) for patients who maintained protocol-defined asthma control at EOT. A total of 41.9% (n = 163 of 389) achieved at least 1 adapted GINA step reduction, increasing to 61.8% (n = 110 of 178) for patients with protocol-defined EOT asthma control. At ANDHI IP baseline, OCS dosages were 5 mg or lower for 40.4% (n = 40 of 99) of OCS-dependent patients. Of OCS-dependent patients, 50.5% (n = 50 of 99) eliminated OCS and 74.7% (n = 74 of 99) achieved dosages of 5 mg or lower at EOT. Conclusions: These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction. © 202

Interactions between environmental and genetic factors in the pathophysiology of Parkinson's disease

10.1080/1521654031000153058IUBMB Life556323-327IULI

Understanding alternative splicing of Cav 1.2 calcium channels for a new approach towards individualized medicine

10.1016/S1674-8301(10)60027-9Journal of Biomedical Research243181-18

Regulation of the expression of major histocompatibility complex class I genes in human colorectal cancer.

Cancer Detection and Prevention153231-23

Adaptive evolution of tetrodotoxin resistance in animals

10.1016/j.tig.2006.08.010Trends in Genetics2211621-62

Locus-specific transcriptional control of HLA genes

Journal of Immunology14962008-2020JOIM

CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency

10.1007/s00424-009-0753-0Pflugers Archiv European Journal of Physiology46021-

Identification of locus-specific DNA-binding factors for the regulation of HLA class-I genes in human colorectal cancer

International Journal of Cancer48SUPPL. 6131-137IJCN